Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease.
Identifieur interne : 000E77 ( Main/Exploration ); précédent : 000E76; suivant : 000E78Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease.
Auteurs : Gertrud Laura Sorensen [Danemark] ; Jacob Kempfner ; Marielle Zoetmulder ; Helge B D. Sorensen ; Poul JennumSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Arousal, Autonomic Nervous System (physiopathology), Electrocardiography, Female, Heart Rate (physiology), Humans, Leg, Male, Middle Aged, Movement (physiology), Parkinson Disease (complications), Polysomnography, REM Sleep Behavior Disorder (complications), Reproducibility of Results, Sleep Stages (physiology).
- MESH :
- complications : Parkinson Disease, REM Sleep Behavior Disorder.
- physiology : Heart Rate, Movement, Sleep Stages.
- physiopathology : Autonomic Nervous System.
- Aged, Arousal, Electrocardiography, Female, Humans, Leg, Male, Middle Aged, Polysomnography, Reproducibility of Results.
Abstract
The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group and the idiopathic rapid-eye-movement sleep behavior disorder group. The heart rate response to leg movement was significantly lower in both Parkinson's groups and in the idiopathic rapid-eye-movement sleep behavior disorder group compared with the control group. The heart rate response for the idiopathic rapid-eye-movement sleep behavior disorder group was intermediate with respect to the control and the parkinsonian groups. The attenuated heart rate response may be a manifestation of the autonomic deficits experienced in Parkinson's disease. The idiopathic rapid-eye-movement sleep behavior disorder patients not only exhibited impaired motor symptoms but also incipient autonomic dysfunction, as revealed by the attenuated heart rate response.
DOI: 10.1002/mds.25012
PubMed: 22555939
Affiliations:
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Le document en format XML
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Gertrud_l@yahoo.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby</wicri:regionArea><wicri:noRegion>Kongens Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name></author><author><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name></author><author><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B D" last="Sorensen">Helge B D. 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Gertrud_l@yahoo.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby</wicri:regionArea><wicri:noRegion>Kongens Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name></author><author><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name></author><author><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B D" last="Sorensen">Helge B D. Sorensen</name></author><author><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arousal</term><term>Autonomic Nervous System (physiopathology)</term><term>Electrocardiography</term><term>Female</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Leg</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Parkinson Disease (complications)</term><term>Polysomnography</term><term>REM Sleep Behavior Disorder (complications)</term><term>Reproducibility of Results</term><term>Sleep Stages (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Heart Rate</term><term>Movement</term><term>Sleep Stages</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Arousal</term><term>Electrocardiography</term><term>Female</term><term>Humans</term><term>Leg</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group and the idiopathic rapid-eye-movement sleep behavior disorder group. The heart rate response to leg movement was significantly lower in both Parkinson's groups and in the idiopathic rapid-eye-movement sleep behavior disorder group compared with the control group. The heart rate response for the idiopathic rapid-eye-movement sleep behavior disorder group was intermediate with respect to the control and the parkinsonian groups. The attenuated heart rate response may be a manifestation of the autonomic deficits experienced in Parkinson's disease. The idiopathic rapid-eye-movement sleep behavior disorder patients not only exhibited impaired motor symptoms but also incipient autonomic dysfunction, as revealed by the attenuated heart rate response.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><noCountry><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><name sortKey="Kempfner, Jacob" sort="Kempfner, Jacob" uniqKey="Kempfner J" first="Jacob" last="Kempfner">Jacob Kempfner</name><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B D" last="Sorensen">Helge B D. Sorensen</name><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name></noCountry><country name="Danemark"><noRegion><name sortKey="Sorensen, Gertrud Laura" sort="Sorensen, Gertrud Laura" uniqKey="Sorensen G" first="Gertrud Laura" last="Sorensen">Gertrud Laura Sorensen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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